The Seminary for Foreign Missions of Yarumal was opened on 3 July 1927 at the initiative of Mgr Michelangelo Builes.
Its purpose is to undertake missionary work in certain regions of Colombia. On 29 June 1937 the Sacred Congregation for the Propagation of the Faith placed it under its jurisdiction and on 20 June 1943 it temporarily approved its constitutions, which are similar to those of other missionary institutes without vows. At present it has 72 priests and 20 lay brothers, and two missions are entrusted to II.